When the Spanish entered the community of Quauhquechollan in Puebla, Mexico in 1519, the territory was part of the Mexica empire and had become a political and military frontier between the Mexica and their allies and the Tlaxcala and their allies, including the Quauhquecholteca. A Spanish leader is seen seated in the lower left of this image and several Spaniards are depicted on horseback at the top of this image.
Image Source
Lienzo de Quauhquechollan (Acervo del Museo Regional “Casa de Alfeñique,” a cargo del Consejo Estatal para la Cultura y las Artes de Puebla)